• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >In vitro photodynamic therapy and quantitative structure-activity relationship studies with stable synthetic near-infrared-absorbing bacteriochlorin photosensitizers.
【2h】

In vitro photodynamic therapy and quantitative structure-activity relationship studies with stable synthetic near-infrared-absorbing bacteriochlorin photosensitizers.

机译：稳定的合成近红外吸收细菌绿素光敏剂的体外光动力疗法和定量构效关系研究。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Photodynamic therapy (PDT) is a rapidly developing approach to treating cancer that combines harmless visible and near-infrared light with a nontoxic photoactivatable dye, which upon encounter with molecular oxygen generates the reactive oxygen species that are toxic to cancer cells. Bacteriochlorins are tetrapyrrole compounds with two reduced pyrrole rings in the macrocycle. These molecules are characterized by strong absorption features from 700 to >800 nm, which enable deep penetration into tissue. This report describes testing of 12 new stable synthetic bacteriochlorins for PDT activity. The 12 compounds possess a variety of peripheral substituents and are very potent in killing cancer cells in vitro after illumination. Quantitative structure-activity relationships were derived, and subcellular localization was determined. The most active compounds have both low dark toxicity and high phototoxicity. This combination together with near-infrared absorption gives these bacteriochlorins great potential as photosensitizers for treatment of cancer.
机译：光动力疗法（PDT）是一种快速发展的癌症治疗方法，它将无害的可见光和近红外光与无毒的可光活化染料相结合，该染料在与分子氧接触时会产生对癌细胞有毒的活性氧。细菌氯霉素是在大环中具有两个还原的吡咯环的四吡咯化合物。这些分子的特征是在700至> 800 nm范围内具有很强的吸收特性，可深入渗透到组织中。本报告介绍了12种新的稳定的合成细菌绿素对PDT活性的测试。这12种化合物具有多种外围取代基，并且在照射后在体外杀死癌细胞方面非常有效。得出定量的构效关系，并确定亚细胞定位。最具活性的化合物同时具有低的暗毒性和高的光毒性。这种结合以及近红外吸收使这些细菌氯霉素具有作为光敏剂治疗癌症的巨大潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号